A study on cancer metastasis and the innovative technology platform, combinatorial genetics en mass (combigem) (4199 words, 18 pages) abstractcancer metastasis is the major cause of death in patients with solid tumors, but our understanding of its molecularand cellular determinants remains limited.
The journal focuses on cancer metastasis and treatment, including the initiation, development, progression, metastasis, and treatment of neoplastic diseases the coverage includes basic, translational and clinical studies related to cancer cell biology, genomics, precision medicine, medical oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neuro-oncology, etc.
While these clinical applications are highly promising, probably the greatest insight to be derived from the study of ctcs relates to understanding the process of cancer metastasis studies of cancer stem cells or progenitors have focused on the characterization of primary tumors. Combinatorial genetics en masse (combigem) for human systems to address these limitations, our combigem technology enables the scalable pooled assembly of barcoded high-order combinatorial genetic libraries for high-throughput screening in human cells with next-generation sequencing this approach leverages an iterative cloning approach starting with an insert library of barcoded dna elements.
Cubic-cancer analysis provides a fundamental platform for the analysis of the metastatic growth and progression of cancer throughout the body results optimized ri cocktail enables whole-body and whole-organ clearing in adult mice. Metastasis is the general term used to describe the spread of cancer cells from the primary tumor to surrounding tissues and to distant organs and is the primary cause of cancer morbidity and mortality 1-8 it is estimated that metastasis is responsible for about 90% of cancer deaths 9 this estimate has changed little in more than 50 years 10,11 metastasis involves a series of sequential and interrelated steps.
The brain is a common site of metastatic disease in patients with breast cancer, which has few therapeutic options and dismal outcomes the purpose of our study was to identify common and rare events that underlie breast cancer brain metastasis.